Details

Autor(en) / Beteiligte

• von Zedtwitz, Katharina
• Matteit, Isabelle
• Michel, Maike
• Feige, Bernd
• Runge, Kimon
• Denzel, Dominik
• Schlump, Andrea
• Nickel, Kathrin
• Schiele, Miriam A
• Berger, Benjamin
• Prüss, Harald
• Urbach, Horst
• Domschke, Katharina
• Tebartz van Elst, Ludger
• Endres, Dominique

Titel

Anti-MOG autoantibody-associated schizophreniform psychosis

Ist Teil von

• Acta neuropsychiatrica, 2022-02, Vol.34 (1), p.47-54

Ort / Verlag

England: Cambridge University Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Autoimmune mechanisms are related to disease development in a subgroup of patients with psychosis. The contribution of immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) is mainly unclear in this context. Therefore, two patients with psychosis and anti-MOG antibodies - detected in fixed cell-based and live cell-based assays - are presented. Patient 1 suffered from late-onset psychosis with singular white matter lesions in magnetic resonance imaging (MRI) and intermittent electroencephalography (EEG) slowing. Patient 2 suffered from a chronic paranoid-hallucinatory disorder with intermittent confusional states, non-specific white matter alterations on MRI, a disorganised alpha rhythm on EEG, and elevated cerebrospinal fluid protein. Both patients had anti-MOG antibody titres of 1 : 320 in serum (reference < 1 : 20). The arguments for and against a causal role for anti-MOG antibodies are discussed. The antibodies could be relevant, but due to moderate titres, they may have caused a rather 'subtle clinical picture' consisting of psychosis instead of 'classical' MOG encephalomyelitis.