Details

Autor(en) / Beteiligte

• Lu, Jean C.
• Vogrin, Sara
• McAuley, Sybil A.
• Lee, Melissa H.
• Paldus, Barbora
• Bach, Leon A.
• Burt, Morton G.
• Clarke, Philip M.
• Cohen, Neale D.
• Colman, Peter G.
• de Bock, Martin I.
• Jane Holmes-Walker, D.
• Jenkins, Alicia J.
• Kaye, Joey
• Keech, Anthony C.
• Kumareswaran, Kavita
• MacIsaac, Richard J.
• McCallum, Roland W.
• Roem, Kerryn
• Sims, Catriona
• Stranks, Stephen N.
• Trawley, Steven
• Ward, Glenn M.
• Sundararajan, Vijaya
• Jones, Timothy W.
• O'Neal, David N.

Titel

Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision

Ist Teil von

• Diabetes research and clinical practice, 2021-09, Vol.179, p.109000-109000, Article 109000

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To compare meal-time glycaemia in adults with type 1 diabetes mellitus (T1D) managed with multiple daily injections (MDI) vs. insulin pump therapy (IPT), using self-monitoring blood glucose (SMBG), following diabetes education. Adults with T1D received carbohydrate-counting education and a bolus calculator: MDI (Roche Aviva Expert) and IPT (pump bolus calculator). All then wore 3-weeks of masked-CGM (Enlite, Medtronic). Meal-times were assessed by two approaches: 1) Set time-blocks (breakfast 06:00–10:00hrs; lunch 11:00–15:00hrs; dinner 17:00–21:00hrs) and 2) Bolus-calculator carbohydrate entries signalling meal commencement. Post-meal masked-CGM time-in-range (TIR) 3.9–10.0 mmol/L was the primary outcome. MDI(n = 61) and IPT (n = 59) participants were equivalent in age, sex, diabetes duration and HbA1c. Median (IQR) education time provided did not differ (MDI: 1.1 h (0.75, 1.5) vs. IPT: 1.1 h (1.0, 2.0); p = 0.86). Overall, daytime (06:00–24:00hrs), lunch and dinner TIR did not differ for MDI vs. IPT participants but was greater for breakfast with IPT in both analyses with a mean difference of 12.8%, (95 CI 4.8, 20.9); p = 0.002 (time-block analysis). After diabetes education, MDI and IPT use were associated with similar day-time glycemia, though IPT users had significantly greater TIR during the breakfast period. With education, meal-time glucose levels are comparable with use of MDI vs. pumps.