Details

Autor(en) / Beteiligte

• Opstal, Tjerk S.J.
• Fiolet, Aernoud T.L.
• van Broekhoven, Amber
• Mosterd, Arend
• Eikelboom, John W.
• Nidorf, Stefan M.
• Thompson, Peter L.
• Duyvendak, Michiel
• van Eck, J.W. Martijn
• van Beek, Eugène A.
• den Hartog, Frank
• Budgeon, Charley A.
• Bax, Willem A.
• Tijssen, Jan G.P.
• El Messaoudi, Saloua
• Cornel, Jan H.
• Nidorf, S.M.
• Xu, X.F.
• Ireland, M.A.
• Latchem, D.
• Whelan, A.
• Hendriks, R.
• Salkani, P.
• Tan, I.W.
• Thompson, A.G.
• Morton, A.M.
• Hockings, B.E.
• Thompson, P.L.
• King, B.
• Cornel, J.H.
• Bakker-Lohmeijer, H.
• Mosterd, A.
• Bunschoten, P.
• The, S.H.K.
• van der Kooi, S.
• Lenderink, T.
• Lardinois, R.G.J.L.
• Hoogslag, P.A.M.
• de Vos, A.
• Jerzewski, A.
• Jansen, S.
• Nierop, P.R.
• van der Knaap, M.
• Swart, H.P.
• Kingma, R.
• Schaap, J.
• Blom, L.B.
• Kuijper, A.F.M.
• Bayraktar-Verver, E.
• van Hessen, M.W.J.
• Engelen, W.C.T.C.
• van Eck, J.W.M.
• van der Ven-Elzebroek, N.
• van Hal, J.M.C.
• Drost, I.M.J.
• den Hartog, F.R.
• van Wijk, D.
• van Beek, E.
• van der Horst, C.
• Bartels, G.L.
• Hendriks, M.
• de Nooijer, C.
• Welten, C.
• Ronner, E.
• Dijkshoorn, A.
• Prins, F.J.
• Rutten, R.N.A.
• Beele, D.P.W.
• Hendriks, I.
• van der Sluis, A.
• Badings, E.A.
• Westendorp, I.C.D.
• Melein, A.
• Römer, Tj.J.
• Bruines, P.
• van de Wal, R.
• Leenders - van Lieshout, I.
• Hemels, M.E.W.
• Meinen-Werner, K.
• de Groot, M.R.
• Post, G.
• Mulder, M.W.C.
• Stuij, S.
• van Nes, E.
• Luyten, P.
• Plomp, J.
• Veldmeijer, S.V.
• Asselman, M.J.
• Scholtus, P.A.

Titel

Colchicine in Patients With Chronic Coronary Disease in Relation to Prior Acute Coronary Syndrome

Ist Teil von

• Journal of the American College of Cardiology, 2021-08, Vol.78 (9), p.859-866

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Colchicine reduces risk of cardiovascular events in patients post–myocardial infarction and in patients with chronic coronary disease. It remains unclear whether this effect is related to the time of onset of treatment following an acute coronary syndrome (ACS). This study investigates risk for major adverse cardiovascular events in relation to history and timing of prior ACS, to determine whether the benefits of colchicine are consistent independent of prior ACS status. The LoDoCo2 (Low-Dose Colchicine 2) trial randomly allocated patients with chronic coronary disease to colchicine 0.5 mg once daily or placebo. The rate of the composite of cardiovascular death, spontaneous myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization was compared between patients with no prior, recent (6-24 months), remote (2-7 years), or very remote (>7 years) ACS; interaction between ACS status and colchicine treatment effect was assessed. In 5,522 randomized patients, risk of the primary endpoint was independent of prior ACS status. Colchicine consistently reduced the primary endpoint in patients with no prior ACS (incidence: 2.8 vs 3.4 events per 100 person-years; hazard ratio [HR]: 0.81; 95% confidence interval [CI]: 0.52-1.27), recent ACS (incidence: 2.4 vs 3.3 events per 100 person-years; HR: 0.75; 95% CI: 0.51-1.10), remote ACS (incidence: 1.8 vs 3.2 events per 100 person-years, HR: 0.55; 95% CI: 0.37-0.82), and very remote ACS (incidence: 3.0 vs 4.3 events per 100 person-years, HR: 0.70; 95% CI: 0.51-0.96) (P for interaction = 0.59). The benefits of colchicine are consistent irrespective of history and timing of prior ACS. (The LoDoCo2 Trial: Low Dose Colchicine for secondary prevention of cardiovascular disease [LoDoCo2] ACTRN12614000093684) [Display omitted]