Details

Autor(en) / Beteiligte

• Matteoli, Filipe Pereira
• Pedrosa-Silva, Francisnei
• Dutra-Silva, Lorena
• Giachini, Admir José

Titel

The global population structure and beta-lactamase repertoire of the opportunistic pathogen Serratia marcescens

Ist Teil von

• Genomics (San Diego, Calif.), 2021-11, Vol.113 (6), p.3523-3532

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Serratia marcescens is a global spread nosocomial pathogen. This rod-shaped bacterium displays a broad host range and worldwide geographical distribution. Here we analyze an international collection of this multidrug-resistant, opportunistic pathogen from 35 countries to infer its population structure. We show that S. marcescens comprises 12 lineages; Sm1, Sm4, and Sm10 harbor 78.3% of the known environmental strains. Sm5, Sm6, and Sm7 comprise only human-associated strains which harbor smallest pangenomes, genomic fluidity and lowest levels of core recombination, indicating niche specialization. Sm7 and Sm9 lineages exhibit the most concerning resistome; blaKPC-2 plasmid is widespread in Sm7, whereas Sm9, also an anthropogenic-exclusive lineage, presents highest plasmid/lineage size ratio and plasmid-diversity encoding metallo-beta-lactamases comprising blaNDM-1. The heterogeneity of resistance patterns of S. marcescens lineages elucidated herein highlights the relevance of surveillance programs, using whole-genome sequencing, to provide insights into the molecular epidemiology of carbapenemase producing strains of this species. •Serratia marcescens population structure comprises 12 lineages.•Sm7 and Sm9 exhibit the most concerning resistome.•The blaKPC-2 gene is highly prevalent in Sm7, a lineage mostly represented by China isolates.•Anthropogenic-only lineages (Sm5, Sm6, and Sm7) harbor smaller pangenomes.•Sm9 exhibits the higher number of plasmids and metallo-betalactamase encoding genomes.