Details

Autor(en) / Beteiligte

• Goi, Leise D.S.
• Altenhofen, Stefani
• Nabinger, Debora D.
• Bonan, Carla D.
• Sato, Douglas K.

Titel

Decreased convulsive threshold and memory loss after anti-NMDAR positive CSF injection in zebrafish

Ist Teil von

• Journal of neuroimmunology, 2021-10, Vol.359, p.577689-577689, Article 577689

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis initially promotes memory deficits, behavioral changes, and epileptic seizures. We developed a new animal model of anti-NMDAR encephalitis using a single cerebroventricular injection of CSF from patients in adult zebrafish. We observed a reduction of the seizure threshold and recent memory deficits in those animals injected with CSF from patients with anti-NMDAR encephalitis. The locomotor activity was similar in the CSF and control groups. This zebrafish model consistently recapitulates symptoms seen in patients with anti-NMDAR encephalitis. It may provide a reliable, fast and cost-effective platform to investigate new therapeutic strategies to anti-NMDAR encephalitis. [Display omitted] •Behaviour, memory and seizures are present in anti-NMDAR encephalitis.•Zebrafish is a reliable and cost-effective model for neurological disorders.•Human CSF anti-NMDAR+ reduced seizure threshold in zebrafish model.•Human CSF anti-NMDAR+ promoted recent memory loss in zebrafish model.