Details

Autor(en) / Beteiligte

• Wang, Pan
• Wang, Jian‐Wei
• Zhang, Wen‐Hua
• Bai, Hongzhen
• Tang, Guping
• Young, David J.

Titel

In Vitro Anticancer Activity of Nanoformulated Mono‐ and Di‐nuclear Pt Compounds

Ist Teil von

• Chemistry, an Asian journal, 2021-10, Vol.16 (19), p.2993-3000

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Nanoformulations of mononuclear Pt complexes cis‐PtCl2(PPh3)2 (1), [Pt(PPh3)2(L−Cys)] ⋅ H2O (3, L−Cys=L‐cysteinate), trans‐PtCl2(PPh2PhNMe2)2 (4; PPh2PhNMe2=4‐(dimethylamine)triphenylphosphine), trans‐PtI2(PPh2PhNMe2)2 (5) and dinuclear Pt cluster Pt2(μ‐S)2(PPh3)4 (2) have comparable cytotoxicity to cisplatin against murine melanoma cell line B16F10. Masking of these discrete molecular entities within the hydrophobic core of Pluronic® F‐127 significantly boosted their solubility and stability, ensuring efficient cellular uptake, giving in vitro IC50 values in the range of 0.87–11.23 μM. These results highlight the potential therapeutic value of Pt complexes featuring stable Pt−P bonds in nanocomposite formulations with biocompatible amphiphilic polymers. Nanoformulations of a class of mononuclear and dinuclear Pt‐based complexes bearing Pt−P bonds have been developed as efficient chemotherapeutic reagents against murine melanoma cell line B16F10.