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Systematic Assessment of 10 Biomarker Candidates Focusing on α‐Synuclein‐Related Disorders
Movement disorders, 2021-12, Vol.36 (12), p.2874-2887
Schulz, Isabel
Kruse, Niels
Gera, Roland G.
Kremer, Thomas
Cedarbaum, Jesse
Barbour, Robin
Zago, Wagner
Schade, Sebastian
Otte, Birgit
Bartl, Michael
Hutten, Samantha J.
Trenkwalder, Claudia
Mollenhauer, Brit
2021
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Schulz, Isabel
Kruse, Niels
Gera, Roland G.
Kremer, Thomas
Cedarbaum, Jesse
Barbour, Robin
Zago, Wagner
Schade, Sebastian
Otte, Birgit
Bartl, Michael
Hutten, Samantha J.
Trenkwalder, Claudia
Mollenhauer, Brit
Titel
Systematic Assessment of 10 Biomarker Candidates Focusing on α‐Synuclein‐Related Disorders
Ist Teil von
Movement disorders, 2021-12, Vol.36 (12), p.2874-2887
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2021
Quelle
MEDLINE
Beschreibungen/Notizen
ABSTRACT Background Objective diagnostic biomarkers are needed to support a clinical diagnosis. Objectives To analyze markers in various neurodegenerative disorders to identify diagnostic biomarker candidates for mainly α‐synuclein (aSyn)‐related disorders (ASRD) in serum and/or cerebrospinal fluid (CSF). Methods Upon initial testing of commercially available kits or published protocols for the quantification of the candidate markers, assays for the following were selected: total and phosphorylated aSyn (pS129aSyn), neurofilament light chain (NfL), phosphorylated neurofilament heavy chain (pNfH), tau protein (tau), ubiquitin C‐terminal hydrolase L1 (UCHL‐1), glial fibrillary acidic protein (GFAP), calcium‐binding protein B (S100B), soluble triggering receptor expressed on myeloid cells 2 (sTREM‐2), and chitinase‐3‐like protein 1 (YKL‐40). The cohort comprised participants with Parkinson's disease (PD, n = 151), multiple system atrophy (MSA, n = 17), dementia with Lewy bodies (DLB, n = 45), tau protein‐related neurodegenerative disorders (n = 80, comprising patients with progressive supranuclear palsy (PSP, n = 38), corticobasal syndrome (CBS, n = 16), Alzheimer's disease (AD, n = 11), and frontotemporal degeneration/amyotrophic lateral sclerosis (FTD/ALS, n = 15), as well as healthy controls (HC, n = 20). Receiver operating curves (ROC) with area under the curves (AUC) are given for each marker. Results CSF total aSyn was decreased. NfL, pNfH, UCHL‐1, GFAP, S100B, and sTREM‐2 were increased in patients with neurodegenerative disease versus HC (P < 0.05). As expected, some of the markers were highest in AD (i.e., UCHL‐1, GFAP, S100B, sTREM‐2, YKL‐40). Within ASRD, CSF NfL levels were higher in MSA than PD and DLB (P < 0.05). Comparing PD to HC, interesting serum markers were S100B (AUC: 0.86), sTREM2 (AUC: 0.87), and NfL (AUC: 0.78). CSF S100B and serum GFAP were highest in DLB. Conclusions Levels of most marker candidates tested in serum and CSF significantly differed between disease groups and HC. In the stratification of PD versus other tau‐ or aSyn‐related conditions, CSF NfL levels best discriminated PD and MSA. CSF S100B and serum GFAP best discriminated PD and DLB. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.28738
Titel-ID: cdi_proquest_miscellaneous_2559434925
Format
–
Schlagworte
alpha-Synuclein - cerebrospinal fluid
,
Alzheimer's disease
,
Amyotrophic Lateral Sclerosis
,
Atrophy
,
Biomarkers
,
Biomarkers - cerebrospinal fluid
,
Brain diseases
,
Calcium-binding protein
,
Candidates
,
Cerebrospinal fluid
,
Chitinase
,
Cohort analysis
,
cohort studies
,
Dementia disorders
,
Frontotemporal Dementia
,
Glial fibrillary acidic protein
,
Humans
,
Hydrolase
,
Lewy bodies
,
Movement disorders
,
Multiple System Atrophy - diagnosis
,
Myeloid cells
,
Neurodegeneration
,
Neurodegenerative diseases
,
outcome research
,
Paralysis
,
Parkinson's disease
,
Parkinson's disease/parkinsonism
,
Patients
,
Progressive supranuclear palsy
,
Protein B
,
Proteins
,
S100b protein
,
Synuclein
,
Tau protein
,
tau Proteins - cerebrospinal fluid
,
Ubiquitin
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