Details

Autor(en) / Beteiligte

• Zhang, Xiao-Ming
• Li, Bao-Sheng
• Wang, Shao-Hua
• Zhang, Kun
• Zhang, Fu-Min
• Tu, Yong-Qiang

Titel

Recent development and applications of semipinacol rearrangement reactions

Ist Teil von

• Chemical science (Cambridge), 2021-07, Vol.12 (27), p.9262-9274

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• As has been well-recognized, semipinacol rearrangement functions as an exceptionally useful methodology in the synthesis of β-functionalized ketones, creation of quaternary carbon centers, and construction of challenging carbocycles. Due to their versatile utilities in organic synthesis, development of novel rearrangement reactions has been a vibrant topic that continues to shape the research field. Recent breakthroughs in novel electrophiles, tandem processes, and enantioselective catalytic transformations further enrich the toolbox of this chemistry and spur the strategic applications of this methodology in natural product synthesis. These achievements will be discussed in this minireview. The recent development of semipinacol rearrangement is reviewed, highlighting its application in β-functionalized ketone synthesis, quaternary carbon formation and total synthesis.