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(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines
Ist Teil von
Journal of asian natural products research, 2022-07, Vol.24 (7), p.641-647
Ort / Verlag
England: Taylor & Francis
Erscheinungsjahr
2022
Quelle
Taylor & Francis
Beschreibungen/Notizen
(±)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC
50
values ranging from 7.9-22.7 μM. Involucrasin A (1) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC
50
values of 25.8 and 26.5 μM, respectively.