Details

Autor(en) / Beteiligte

• Liu, Lu
• Li, Xiao-Hong
• Ma, Xiao-Xia
• Tan, Wen-Hong
• Ma, Wen-Zhe
• Shen, Yun-Fu
• Khan, Afsar
• Zhou, Zhi-Hong
• Yang, Zhu-Ya

Titel

(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines

Ist Teil von

• Journal of asian natural products research, 2022-07, Vol.24 (7), p.641-647

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Quelle

Taylor & Francis

Beschreibungen/Notizen

• (±)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC 50 values ranging from 7.9-22.7 μM. Involucrasin A (1) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC 50 values of 25.8 and 26.5 μM, respectively.