Details

Autor(en) / Beteiligte

• Harris, Rachel A.
• Stevens, Jadd. M.
• Pickering, Diane L.
• Althof, Pamela A.
• Smith, Lynette M.
• Sanmann, Jennifer N.
• Dave, Bhavana J.

Titel

Frequency, variations, and prognostic implications of chromosome 14q32 deletions in chronic lymphocytic leukemia

Ist Teil von

• Leukemia research, 2021-11, Vol.110, p.106665-106665, Article 106665

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Abnormalities of 14q32 occur in a high frequency of cases with CLL.•Deletions within the IGH variable region range in size in cases with CLL.•Minimum deleted region of 14q32 encompassed LINC00221.•Cases with sole 14q32 deletions had a shorter median TTFT than cases with sole 13q abnormalities. The clinical implications of deletions within chromosome 14q32 in CLL pathogenesis remain unclear. We examined the frequency of 14q32 deletions among CLL cases by karyotype and FISH, categorized the variation using genomic microarray, and assessed the prognostic impact by time-to-first-treatment (TTFT) analysis. A 14q32 abnormality was detected in 35 % (245/698) of cases, with the majority containing a 5′ partial telomeric 14q32 deletion. These deletions within the IGH variable region (35/40) ranged from 236 kb to 1.4 Mb involving FAM30A, ADAM6, LINC00226, and LINC00221. The 214 kb minimum deleted region implicated in CLL pathogenesis encompassed LINC00221. Cases with a 14q32 deletion had a shorter median TTFT compared to cases with a sole deletion/nullisomy 13q, a good prognostic indicator, and longer than cases with a sole deletion of 11q or 17p, conferring an unfavorable prognosis. This investigation underscores the importance of comprehensive testing to apprehend the implications of 14q32 deletions in CLL.