Details

Autor(en) / Beteiligte

• Nazari, Hojjatollah
• Naei, Vahid Yaghoubi
• Tabasi, Asieh Heirani
• Badripour, Abolfazl
• Akbari Asbagh, Reza
• Keramati, Mohammad Reza
• Sharifi, Amirsina
• Behboudi, Behnam
• Kazemeini, Alireza
• Abbasi, Maryam
• Keshvari, Amir
• Ahmadi Tafti, Seyed Mohsen

Titel

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

Ist Teil von

• Inflammatory bowel diseases, 2022-01, Vol.28 (1), p.133-142

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues and organs. This advanced therapeutic approach has demonstrated great potential in addressing the limitations of medical and surgical procedures for treating perineal fistula in patients with Crohn’s disease. Recent developments in stem cell technology have led to a massive good manufacturing practices (GMPs) production of various stem cells, including mesenchymal and embryonic cells, along with induction of pluripotent stem cells to repair damaged tissues in the fistula. The recent advances in separation and purification of exosomes, as biologic nanovesicles carrying anti-inflammatory and regenerative agents, have made them powerful tools to treat this inflammatory disease. Further, tremendous advances in nanotechnology, biomaterials, and scaffold fabrication methods enable tissue engineering methods to synthesize tissue-like structures to assist surgical techniques. This review focuses on advanced regenerative-based methods including stem cell therapy, exosome therapy, and tissue engineering used in the treatment of perianal fistula. Relevant in vitro and in vivo studies and the latest innovations in implementation of regenerative medicine for this disease are also separately reviewed. Additionally, current challenges regarding implementation of g stem cells, exosomes, and tissue engineering methods for bridging the gaps between laboratory findings and clinic application will be discussed. Graphical Abstract Graphical Abstract Clinical medical treatments and regenerative medicine approach for the treatment of perianal fistula. Various systemic therapy and surgical procedures are performed in clinics for healing perianal fistula. Regenerative medicine can enhance treatment efficacy through stem cell therapy, implementing exosomes, and fabricating tissue-like structures via tissue engineering.