Details

Autor(en) / Beteiligte

• Murai, Ryosuke
• Kawase, Yuichi
• Taniguchi, Tomohiko
• Morimoto, Takeshi
• Kadota, Kazushige
• Ohya, Masanobu
• Shimada, Takenobu
• Maruo, Takeshi
• Fuku, Yasushi
• Komiya, Tatsuhiko
• Ando, Kenji
• Hanyu, Michiya
• Kanamori, Norio
• Aoyama, Takeshi
• Murata, Koichiro
• Onodera, Tomoya
• Yamazaki, Fumio
• Kitai, Takeshi
• Furukawa, Yutaka
• Koyama, Tadaaki
• Miyake, Makoto
• Izumi, Chisato
• Nakagawa, Yoshihisa
• Yamanaka, Kazuo
• Mitsuoka, Hirokazu
• Shirotani, Manabu
• Kato, Masashi
• Miki, Shinji
• Nakajima, Hiroyuki
• Hirano, Yutaka
• Miyazaki, Shunichi
• Saga, Toshihiko
• Sugioka, Sachiko
• Matsuda, Shintaro
• Matsuda, Mitsuo
• Ogawa, Tatsuya
• Nagao, Kazuya
• Inada, Tsukasa
• Nakayama, Shogo
• Mabuchi, Hiroshi
• Takeuchi, Yasuyo
• Sakamoto, Hiroki
• Sakaguchi, Genichi
• Yamane, Keiichiro
• Eizawa, Hiroshi
• Toyofuku, Mamoru
• Tamura, Takashi
• Iwakura, Atsushi
• Ishii, Mitsuru
• Akao, Masaharu
• Shiraga, Kotaro
• Minamino-Muta, Eri
• Kato, Takao
• Inoko, Moriaki
• Ueyama, Koji
• Ikeda, Tomoyuki
• Himura, Yoshihiro
• Komasa, Akihiro
• Ishii, Katsuhisa
• Hotta, Kozo
• Sato, Yukihito
• Fujiwara, Keiichi
• Kato, Yoshihiro
• Kouchi, Ichiro
• Inuzuka, Yasutaka
• Ikeguchi, Shigeru
• Miwa, Senri
• Maeda, Chiyo
• Shinoda, Eiji
• Nishizawa, Junichiro
• Jinnai, Toshikazu
• Higashitani, Nobuya
• Kitano, Mitsuru
• Morikami, Yuko
• Kitaguchi, Shouji
• Minatoya, Kenji
• Kimura, Takeshi
• on behalf of the CURRENT AS Registry Investigators

Titel

Concomitant Mitral Regurgitation in Severe Aortic Stenosis　― A Report From the CURRENT AS Registry

Ist Teil von

• Circulation Journal, 2022/02/25, Vol.86(3), pp.427-437

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background:The clinical significance of concomitant mitral regurgitation (MR) has not been well addressed in patients with severe aortic stenosis (AS).Methods and Results:We analyzed 3,815 patients from a retrospective multicenter registry of severe AS in Japan (CURRENT AS registry). We compared the clinical outcomes between patients with moderate/severe MR and with none/mild MR according to the initial treatment strategy (initial aortic valve replacement [AVR] or conservative strategy). The primary outcome measure was a composite of aortic valve-related death or heart failure hospitalization. At baseline, moderate/severe MR was present in 227/1,197 (19%) patients with initial AVR strategy and in 536/2,618 (20%) patients with a conservative strategy. The crude cumulative 5-year incidence of the primary outcome measure was significantly higher in patients with moderate/severe MR than in those with none/mild MR, regardless of the initial treatment strategy (25.2% vs. 14.4%, P<0.001 in the initial AVR strategy, and 63.3% vs. 40.7%, P<0.001 in the conservative strategy). After adjusting confounders, moderate/severe MR was not independently associated with higher risk for the primary outcome measure in the initial AVR strategy (hazard ratio [HR] 1.11, 95% confidence interval [CI] 0.67–1.83, P=0.69), and in the conservative strategy (HR 1.13, 95% CI 0.93–1.37, P=0.22).Conclusions:Concomitant moderate/severe MR was not independently associated with higher risk for the primary outcome measure regardless of the initial treatment strategy.