Details

Autor(en) / Beteiligte

• Magalhães, Thamires Naela Cardoso
• Gerbelli, Christian Luiz Baptista
• Pimentel-Silva, Luciana Ramalho
• de Campos, Brunno Machado
• de Rezende, Thiago Junqueira Ribeiro
• Rizzi, Liara
• Joaquim, Helena Passarelli Giroud
• Talib, Leda Leme
• Forlenza, Orestes Vicente
• Cendes, Fernando
• Balthazar, Marcio Luiz Figueredo

Titel

Differences in structural and functional default mode network connectivity in amyloid positive mild cognitive impairment: a longitudinal study

Ist Teil von

• Neuroradiology, 2022, Vol.64 (1), p.141-150

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2022

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• Purpose Default mode network (DMN) has emerged as a potential biomarker of Alzheimer’s disease (AD); however, it is not clear whether it can differentiate amnestic mild cognitive impairment with altered amyloid (aMCI-Aβ +) who will evolve to AD. We evaluated if structural and functional connectivity (FC), hippocampal volumes (HV), and cerebrospinal fluid biomarkers (CSF—Aβ 42 , p-Tau, and t-Tau) can differentiate aMCI-Aβ + converters from non-converters. Methods Forty-eight individuals (18 normal controls and 30 aMCI subjects in the AD continuum — with altered Aβ 42 in the CSF) were followed up for an average of 13 months. We used MultiAtlas, UF 2 C, and Freesurfer software to evaluate diffusion tensor imaging, FC, and HV, respectively, INNOTEST® kits to measure CSF proteins, and neuropsychological tests. Besides, we performed different MANOVAs with further univariate analyses to differentiate groups. Results During follow-up, 8/30 aMCI-Aβ + converted (26.6%) to AD dementia. There were no differences in multivariate analysis between groups in CSF biomarkers (p = 0.092) or at DMN functional connectivity ( p  = 0.814). aMCI-Aβ + converters had smaller right HV than controls ( p  = 0.013), and greater right cingulum parahippocampal bundle radial diffusivity than controls ( p  < 0.001) and non-converters ( p  = 0.036). Conclusion In this exploratory study, structural, but not functional, DMN connectivity alterations may differentiate aMCI-Aβ + subjects who converted to AD dementia.