Details

Autor(en) / Beteiligte

• Jang, Dong‐Jin
• Lee, Sukhyun
• Lee, Juyeol
• Moon, Dohyun
• Rhee, Young Ho

Titel

Palladium‐Catalyzed Asymmetric Decarboxylative Addition of β‐Keto Acids to Heteroatom‐Substituted Allenes

Ist Teil von

• Angewandte Chemie International Edition, 2021-10, Vol.60 (41), p.22166-22171

Auflage

International ed. in English

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The Pd‐catalyzed asymmetric addition reaction of β‐keto acids to heteroatom‐substituted allene is reported. This reaction generates β‐substituted ketones in an asymmetric manner through a branch‐selective decarboxylative allylation pathway. The reaction accommodates various alkoxyallenes as well as amidoallenes. We report here an asymmetric decarboxylative allylation reaction initiated by the hydrocarboxylation reaction of heteroatom‐substituted allene. The reaction works particularly well with heteroatom‐substituted allenes such as alkoxyallenes and amidoallenes. A number of aryl and alkyl β‐keto acids as well as malonic acid mono‐phenyl ester participates in the reaction to generate γ,δ‐unsaturated carbonyl compounds possessing stereogenic heteroatom substituents at the β‐position.