Details

Autor(en) / Beteiligte

• Morgan, Katrina M.
• Yazer, Mark H.
• Triulzi, Darrell J.
• Strotmeyer, Stephen
• Gaines, Barbara A.
• Leeper, Christine M.

Titel

Safety profile of low‐titer group O whole blood in pediatric patients with massive hemorrhage

Ist Teil von

• Transfusion (Philadelphia, Pa.), 2021-07, Vol.61 (S1), p.S8-S14

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background Low‐titer Group O Whole Blood (LTOWB) is used with increasing frequency in adult and pediatric trauma and massive bleeding transfusion protocols. There is a risk of acute hemolytic reactions in non‐group O recipients due to the passive transfusion of anti‐A and anti‐B in the LTOWB. This study investigated the hemolysis risk among pediatric recipients of LTOWB. Study design and methods Blood bank records were queried for pediatric recipients of LTOWB between June 2016 and August 2020 and merged with clinical data. The primary outcome was laboratory evidence of hemolysis as manifested by changes in lactate dehydrogenase (LDH), haptoglobin, total bilirubin, reticulocyte count, potassium, and creatinine. Per protocol, these values were collected on hospital days 0–2 for recipients of LTOWB. Transfusion reactions were reported to the hospital's blood bank. Results Forty‐seven children received LTOWB transfusion between 2016 and 2020; 21 were group O and 26 were non‐group O. The groups were comparable in terms of the total volume of transfused blood products, demographics, and clinical outcomes. The most common indication for LTOWB transfusion was hemorrhagic shock due to trauma. There were no clinically or statistically significant differences in baseline, post‐transfusion day 1, or post‐transfusion day 2 hemolysis markers between the group O and non‐group O LTOWB recipients. There were no adverse events or transfusion reactions reported. Discussion Use of up to 40 ml/kg of LTOWB appears to be serologically safe for children in hemorrhagic shock.