Annals of biomedical engineering, 2021-12, Vol.49 (12), p.3356-3373
2021
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Details
- Autor(en) / Beteiligte
- Titel
- A Mesoscale Computational Model for Microvascular Oxygen Transfer
- Ist Teil von
- Annals of biomedical engineering, 2021-12, Vol.49 (12), p.3356-3373
- Ort / Verlag
- Cham: Springer International Publishing
- Erscheinungsjahr
- 2021
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0090-6964eISSN: 1573-9686DOI: 10.1007/s10439-021-02807-xTitel-ID: cdi_proquest_miscellaneous_2546600093
- Format
- –
- Schlagworte
- Adequacy, Biochemistry, Biological and Medical Physics, Biomedical and Life Sciences, Biomedical engineering, Biomedical Engineering and Bioengineering, Biomedicine, Biophysics, Blood flow, Cancer, Classical Mechanics, Computer applications, Engineering, Hematocrit, Heterogeneity, Mathematical models, Microenvironments, Microvasculature, Oxygen, Oxygen transfer, Oxygenation, Physiology, Radiation therapy, Simulation, Tissues, Virtual Physiological Human