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Herpesviruses and the hidden links to Multiple Sclerosis neuropathology
Ist Teil von
Journal of neuroimmunology, 2021-09, Vol.358, p.577636-577636, Article 577636
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2021
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
Herpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous herpesvirus antigens are similar to myelin proteins. Other mechanisms described here include the activity of cytokines and autoantibodies produced by the autoreactive T and B cells, respectively, viral déjà vu, epitope spreading, CD46 receptor engagement, impaired remyelination etc. Overall, this review addresses the host-parasite association of viruses with MS.
•Herpesviruses have an age-old clinical association with multiple sclerosis pathology.•Numerous antigens of herpesviruses are similar to myelin proteins.•Herpesvirus can trigger activation of T and B-cells leading to MS pathophysiology.•Oligodendrocyte precursors cells infection may cause impairment in remyelination.•HSV-1, HHV-6 and VZV may reactivate multiple sclerosis-associated retroviruses.