Details

Autor(en) / Beteiligte

• Liu, Yi-Zhang
• Zhang, Chi
• Jiang, Jie-Feng
• Cheng, Zhe-Bin
• Zhou, Zheng-Yang
• Tang, Mu-Yao
• Sun, Jia-Xiang
• Huang, Liang

Titel

Angiopoietin-like proteins in atherosclerosis

Ist Teil von

• Clinica chimica acta, 2021-10, Vol.521, p.19-24

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Angiopoietin-like proteins are involved in atherosclerosis-related pathological processes.•Angiopoietin-like proteins can be the roles as independent predictive value of biomarkers for atherosclerosis therapy.•The precise mechanism that Angiopoietin-like proteins regulate atherosclerosis process deserve to be further explored. Atherosclerosis, as a chronic inflammatory disease within the arterial wall, is a leading cause of morbidity and mortality worldwide due to its role in myocardial infarction, stroke and peripheral artery disease. Additional evidence is emerging that the angiopoietin-like (ANGPTL) family of proteins participate in the pathology of this disease process via endothelial dysfunction, inflammation, dyslipidemia, calcification, foam cell formation and platelet activation. This review summarizes current knowledge on the ANGPTL family of proteins in atherosclerosis related pathological processes. Moreover, the potential value of ANGPTL family proteins as predictive biomarkers in atherosclerosis is discussed. Given the attractive role of ANGPTL3, ANGPTL4, ANGPTL8 in atherosclerotic dyslipidemia via regulation of lipoprotein lipase (LPL), antisense oligonucleotide or/and monoclonal antibody-based inactivation of these proteins represent potential atherosclerotic therapies.