Details

Autor(en) / Beteiligte

• Georghiou, Sophia B
• Penn-Nicholson, Adam
• de Vos, Margaretha
• Macé, Aurélien
• Syrmis, Melanie W
• Jacob, Kevin
• Mape, Alyanna
• Parmar, Heta
• Cao, Yuan
• Coulter, Chris
• Ruhwald, Morten
• Pandey, Sushil K
• Schumacher, Samuel G
• Denkinger, Claudia M

Titel

Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection

Ist Teil von

• Diagnostic microbiology and infectious disease, 2021-09, Vol.101 (1), p.115397-115397, Article 115397

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •The Xpert MTB/XDR assay has a limit of detection for M. tuberculosis equivalent to Xpert MTB/RIF.•The Xpert MTB/XDR assay reliably detects a wide range of globally relevant isoniazid-, ethionamide-, fluoroquinolone- and second-line injectable resistance mutations.•The Xpert MTB/XDR assay demonstrates potential for heteroresistance detection. In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR® assay demonstrated equivalent limit of detection to Xpert MTB/RIF®, detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection.