Details

Autor(en) / Beteiligte

• Martínez-Cerón, Elisabet
• Casitas, Raquel
• Galera, Raúl
• Sánchez-Sánchez, Begoña
• Zamarrón, Ester
• Garcia-Sanchez, Aldara
• Jaureguizar, Ana
• Cubillos-Zapata, Carolina
• Garcia-Rio, Francisco

Titel

Contribution of sleep characteristics to the association between obstructive sleep apnea and dyslipidemia

Ist Teil von

• Sleep medicine, 2021-08, Vol.84, p.63-72

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2021

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Little information is available about the association of obstructive sleep apnea (OSA) with atherogenic dyslipidemia and the contribution of sleep characteristics to lipid alterations. We compare dyslipidemia prevalence among non-apneic subjects and mild-severe OSA patients to identify the sleep characteristics that are independently associated with dyslipidemia and serum lipid levels in OSA patients. We recruited 809 consecutive patients who had been referred for polysomnography study by OSA suspicion. Anthropometric characteristics, body composition and comorbidities were recorded. Spirometry and 24-h ambulatory blood pressure monitoring were performed the same day of the sleep study. The day after attended polysomnography, fasting blood samples were drawn to measure the lipid profile. Dyslipidemia prevalence increased with the presence of OSA, from non-OSA subjects to mild, moderate and severe OSA patients (31%, 33%, 42% and 51%, respectively; p < 0.001). After adjusting for sex, age, body mass index and smoking habit, only severe OSA had an independent association with dyslipidemia when compared to non-OSA subjects (adjusted odds ratio 1.71, 95%CI 1.09 to 2.69, p = 0.019). In OSA patients, multivariate logistic regression identified active smoking, apnea-hypopnea index (AHI) and mean nocturnal saturation as variables independently associated with dyslipidemia. However, in these patients, arousal index, slow wave sleep duration and REM latency were also independently associated with cholesterol and low-density lipoprotein levels. The association between dyslipidemia and OSA is limited to severe patients, with high AHI and nocturnal hypoxemia. However, sleep fragmentation and increased sympathetic activity could also contribute to OSA-related lipid dysregulation. •Severe obstructive sleep apnea is associated with dislipidemia.•Arousal index and slow wave sleep duration are also related to lipid profile.•Intermittent hypoxia, sleep fragmentation and sympathetic activity could contribute to lipid metabolism dysregulation.