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A SNP within the PMCH gene as a molecular marker associated with fertility traits in Angus and Brangus beef heifers raised under a desert environment
Ist Teil von
Tropical animal health and production, 2021-07, Vol.53 (3), p.355-355, Article 355
Ort / Verlag
Dordrecht: Springer Netherlands
Erscheinungsjahr
2021
Link zum Volltext
Quelle
SpringerLink (Online service)
Beschreibungen/Notizen
Components of the GH/IGF1 endocrine axis regulate growth and reproductive traits in cattle. The pro-melanin-concentrating hormone (
PMCH
) gene located within chromosome 5 belongs to this axis. Objective herein was to evaluate
PMCH
single-nucleotide polymorphisms (SNPs) as molecular markers associated with age at first calving, calving interval, and age at second calving in Angus and Brangus beef heifers raised in desert conditions. Five SNPs within the
PMCH
gene were included in the study. Three of these SNPs had minor allele frequency > 10% and only one SNP did not deviate from Hardy–Weinberg equilibrium. A genotype to phenotype association analyses was performed using a mixed-effects model which included phenotype as the response variable, SNP genotype, breed, year of birth and age of dam as fixed terms, and sire as a random effect. Genotypes from the SNP rs135033882 were found to be associated (
P
< 0.05) with all evaluated fertility traits, and the term breed resulted as a significant source of variation only for age at second calving. The allele A was the favorable allele because it decreased the age at first calving 98.6 days, the calving interval 85.3 days, and the age at second calving 183.1 days, in Angus and Brangus heifers. In conclusion, we proposed a SNP within the
PMCH
gene as a potential candidate marker associated with reproductive performance in Angus and Brangus beef heifers raised in a desert climate.