Details

Autor(en) / Beteiligte

• Souza, Lucas Lacerda de
• Cáceres, Cinthia Verónica Bardález López de
• Vargas, Pablo Agustin
• Lopes, Márcio Ajudarte
• Santos‐Silva, Alan Roger
• Silva, Wagner Gomes da
• Prado‐Ribeiro, Ana Carolina
• Brandão, Thais Bianca
• Pereira, Juliana
• Mesquita, Ricardo Alves
• Pontes, Flávia Sirotheau Correa
• González‐Arriagada, Wilfredo Alejandro
• Pedraza, Ricardo Martinez
• Andrade, Bruno Augusto Benevenuto de
• Romañach, Mario José
• Soares, Ciro Dantas
• Carvalho, Maria Goretti Freire de
• Pires, Fabio Ramôa
• Carlos, Roman
• Fonseca, Felipe Paiva
• Pontes, Hélder Antônio Rebelo
• Almeida, Oslei Paes

Titel

Plasmacytoma and plasma cell myeloma affecting the jaws: A multi‐institutional collaborative study

Ist Teil von

• Journal of oral pathology & medicine, 2021-07, Vol.50 (6), p.613-621

Ort / Verlag

Denmark: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods Paraffin‐embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow‐up status were retrieved from the pathology reports. Results Fifty‐two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow‐up was 26.6%. Conclusion Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.