Details

Autor(en) / Beteiligte

• Di Sanza, Riccardo
• Nguyen, Thi Le Nhon
• Iqbal, Naeem
• Argent, Stephen P
• Lewis, William
• Lam, Hon Wai

Titel

Enantioselective nickel-catalyzed arylative and alkenylative intramolecular 1,2-allylations of tethered allene-ketones

Ist Teil von

• Chemical science (Cambridge), 2020-01, Vol.11 (9), p.241-246

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The enantioselective nickel-catalyzed reaction of tethered allene-ketones with (hetero)arylboronic acids or potassium vinyltrifluoroborate is described. Carbonickelation of the allene gives allylnickel species, which undergo cyclization by 1,2-allylation to produce chiral tertiary-alcohol-containing aza- and carbocycles in high diastereo- and enantioselectivities. Chiral tertiary-alcohol-containing aza- and carbocycles are produced in high diastereo- and enantioselectivities by the nickel-catalyzed reaction of tethered allene-ketones with (hetero)arylboronic acids or potassium vinyltrifluoroborate.