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Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients
Ist Teil von
Immunology letters, 2021-08, Vol.236, p.68-77
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2021
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
•Co-infection HTLV-1/HIV impacted the biomarker profile of HTLV patients.•Increase in the inflammatory response is hallmarked in the presence of co-infection.•HAM(+) patients are characterized by higher levels of CXCL8, CCL2, CXCL-10 and TNF.
The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The plasma levels of leukotrienes and chemokines/cytokines were quantified by ELISA and Cytometric Bead Array. A total of 138 volunteers were enrolled and divided into two subgroups (“HTLV-1(+)HIV(-)” and “HTLV-1(+)(HIV(+)”), which were categorized according to the HTLV-1-associated neurological disease (AS, pHAM and HAM). Reference controls were BD and HIV mono-infected patients. HAM(+) exhibited higher CD4+ T-cell counts as compared to HIV+ mono-infected patients and lower HTLV-1 proviral load as compared to mono-infected HAM(-) patients. AS(+) exhibited higher levels of CysLT, CXCL8/IL-8 and lower levels of CCL5/RANTES as compared to AS(-). Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as compared to HAM(-) subgroup.