Details

Autor(en) / Beteiligte

• Tan, Xiaoping
• Liu, Yang
• Liu, Yan
• Zhang, Taiming
• Cong, Shuyan

Titel

Dysregulation of long non‐coding RNAs and their mechanisms in Huntington's disease

Ist Teil von

• Journal of neuroscience research, 2021-09, Vol.99 (9), p.2074-2090

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Extensive alterations in gene regulatory networks are a typical characteristic of Huntington's disease (HD); these include alterations in protein‐coding genes and poorly understood non‐coding RNAs (ncRNAs), which are associated with pathology caused by mutant huntingtin. Long non‐coding RNAs (lncRNAs) are an important class of ncRNAs involved in a variety of biological functions, including transcriptional regulation and post‐transcriptional modification of many targets, and likely contributed to the pathogenesis of HD. While a number of changes in lncRNAs expression have been observed in HD, little is currently known about their functions. Here, we discuss their possible mechanisms and molecular functions, with a particular focus on their roles in transcriptional regulation. These findings give us a better insight into HD pathogenesis and may provide new targets for the treatment of this neurodegenerative disease.