Details

Autor(en) / Beteiligte

• Tian, Min
• Wu, Zhihui
• Heng, Jinghui
• Chen, Fang
• Guan, Wutai
• Zhang, Shihai

Titel

Novel advances in understanding fatty acid–binding G protein–coupled receptors and their roles in controlling energy balance

Ist Teil von

• Nutrition reviews, 2022-01, Vol.80 (2), p.187-199

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2022

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Diabetes, obesity, and other metabolic diseases have been recognized as the main factors that endanger human health worldwide. Most of these metabolic syndromes develop when the energy balance in the body is disrupted. Energy balance depends upon the systemic regulation of food intake, glucose homeostasis, and lipid metabolism. Fatty acid–binding G protein–coupled receptors (GPCRs) are widely expressed in various types of tissues and cells involved in energy homeostasis regulation. In this review, the distribution and biological functions of fatty acid–binding GPCRs are summarized, particularly with respect to the gut, pancreas, and adipose tissue. A systematic understanding of the physiological functions of the fatty acid–binding GPCRs involved in energy homeostasis regulation will help in identifying novel pharmacological targets for metabolic diseases.