Details

Autor(en) / Beteiligte

• Vaamonde-García, Carlos
• Flórez-Fernández, Noelia
• Torres, María Dolores
• Lamas-Vázquez, María J.
• Blanco, Francisco J.
• Domínguez, Herminia
• Meijide-Faílde, Rosa

Titel

Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis

Ist Teil von

• Carbohydrate polymers, 2021-04, Vol.258, p.117692-117692, Article 117692

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •Chemical composition varies between fucoidans and defines their biological properties.•Ratio sulfate:fucose seems critically relevant for fucoidan activity.•Differential effect of fucoidans between articular chondrocytes and synoviocytes.•Fucoidans shows anti-inflammatory, antioxidant, and mitochondrial protection effect.•Involvement of activation of Nrf-2/HO-1 pathway and inhibition of NF-κB signaling. Osteoarthritis (OA) is the most prevalent articular chronic disease. Although, to date there is no cure for OA. Fucoidans, one of the main therapeutic components of brown algae, have emerged as promising molecules in OA treatment. However, the variability between fucoidans makes difficult the pursuit of the most suitable candidate to target specific pathological processes. By an in vitro experimental approach in chondrocytes and fibroblast-like synoviocytes, we observed that chemical composition of fucoidan, and specifically the phlorotannin content and the ratio sulfate:fucose, seems critically relevant for its biological activity. Nonetheless, other factors like concentration and molecular weight of the fucoidan may influence on its beneficial effects. Additionally, a cell-type dependent response was also detected. Thus, our results shed light on the potential use of fucoidans as natural molecules in the treatment of key pathological processes in the joint that favor the development of rheumatic disorders as OA.