Details

Autor(en) / Beteiligte

• Chen, Tsung‐Po
• Lin, Wen‐Yuan
• Chiang, Chien‐Hsieh
• Shen, Ting‐Hsin
• Huang, Kuo‐Chin
• Yang, Kuen‐Cheh

Titel

Metabolically healthy obesity and risk of non‐alcoholic fatty liver disease severity independent of visceral fat

Ist Teil von

• Journal of gastroenterology and hepatology, 2021-10, Vol.36 (10), p.2903-2910

Ort / Verlag

Australia: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background and Aim Obesity and metabolic conditions may be related to non‐alcoholic fatty liver disease (NAFLD). The study assesses the risk of NAFLD according to obesity and metabolic health status in a community‐based population. Methods A total of 1651 subjects were recruited from the community. Individuals were categorized into four groups according to obesity status (defined as a body mass index ≥ 25 kg/m2) and metabolically healthy status: metabolically healthy nonobesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy nonobesity (MUHNO), and metabolically unhealthy obesity (MUHO). NAFLD was diagnosed based on a semiquantitative ultrasonography measurement. Visceral fat was assessed through bioelectrical impedance analysis and is shown by tertile (T1, T2, and T3). A proportional odds model was used to assess the cumulative risk of NAFLD. Results The NAFLD prevalence was 26.7%, 62.8%, 47.0%, and 76.7% in subjects with MHNO, MHO, MUHNO, and MUHO, respectively (P < 0.0001). After adjustment for age, sex, exercise habits, alcohol consumption, cigarette smoking, and visceral fat, the odds ratios for more severe NAFLD were 2.44 (95% confidence interval [CI]: 1.64–3.65), 2.75 (95% CI: 1.91–3.94), and 7.41 (95% CI: 4.94–11.12) in the MHO, MUHNO, and MUHO groups, respectively, compared with the MHNO group. In addition, the odds ratios for more severe NAFLD significantly increased with the increase in visceral fat level (T2 vs T1: 3.83, 95% CI: 2.65–5.53; T3 vs T1: 9.17, 95% CI: 5.33–15.79). Conclusion Both obesity and metabolically unhealthy status were associated with a higher risk of NAFLD independent of visceral fat level.