Details

Autor(en) / Beteiligte

• Shelton, Janie F
• Shastri, Anjali J
• Ye, Chelsea
• Weldon, Catherine H
• Filshtein-Sonmez, Teresa
• Coker, Daniella
• Symons, Antony
• Esparza-Gordillo, Jorge
• Aslibekyan, Stella
• Auton, Adam

Titel

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

Ist Teil von

• Nature genetics, 2021-06, Vol.53 (6), p.801-808

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes.