Details

Autor(en) / Beteiligte

• Esona, Mathew D
• Ward, M Leanne
• Wikswo, Mary E
• Rustempasic, Slavica M
• Gautam, Rashi
• Perkins, Charity
• Selvarangan, Rangaraj
• Harrison, Christopher J
• Boom, Julie A
• Englund, Janet A
• Klein, Eileen J
• Staat, Mary Allen
• McNeal, Monica M
• Halasa, Natasha
• Chappell, James
• Weinberg, Geoffrey A
• Payne, Daniel C
• Parashar, Umesh D
• Bowen, Michael D

Titel

Rotavirus Genotype Trends and Gastrointestinal Pathogen Detection in the United States, 2014–2016: Results From the New Vaccine Surveillance Network

Ist Teil von

• The Journal of infectious diseases, 2021-11, Vol.224 (9), p.1539-1549

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Following the implementation of rotavirus vaccination in 2006, severe acute gastroenteritis (AGE) due to group A rotavirus (RVA) has substantially declined in US children. We report the RVA genotype prevalence as well as coinfection data from 7 US New Vaccine Surveillance Network sites during 3 consecutive RVA seasons, 2014–2016 Methods A total of 1041 stool samples that tested positive for RVA by Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention (CDC) for RVA genotyping and multipathogen testing. Results A total of 795 (76%) samples contained detectable RVA when tested at the CDC. Rotavirus disease was highest in children < 3 years of age. Four G types (G1, G2, G9, and G12) accounted for 94.6% of strains while 2 P types (P[4] and P[8]) accounted for 94.7% of the strains. Overall, G12P[8] was the most common genotype detected in all 3 seasons. Stepwise conditional logistic analysis found year and study site were significant predictors of genotype. Twenty-four percent of RVA-positive specimens contained other AGE pathogens. Conclusions G12P[8] predominated over 3 seasons, but strain predominance varied by year and study site. Ongoing surveillance provides continuous tracking and monitoring of US genotypes during the postvaccine era. Rotavirus group A surveillance in 7 US New Vaccine Surveillance Network sites during the 2014–2016 rotavirus season shows genotype G12P[8] as the most common strain over the 3 seasons, but predominance varied by year and study site.