Details

Autor(en) / Beteiligte

• Grenadyorov, A.S.
• Zhulkov, M.O.
• Solovyev, А.А.
• Oskomov, K.V.
• Semenov, V.A.
• Chernyavskiy, A.M.
• Sirota, D.A.
• Karmadonova, N.A.
• Malashchenko, V.V.
• Litvinova, L.S.
• Khaziakhmatova, O.G.
• Gazatova, N.D.
• Khlusov, I.A.

Titel

Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy

Ist Teil von

• Materials Science & Engineering C, 2021-04, Vol.123, p.112002-112002, Article 112002

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems. [Display omitted] •The a-C:H:SiOx coating improves the corrosion resistance of Ti6Al4V titanium alloy.•The a-C:H:SiOx coating deposition provides a negative electrostatic potential for the surface.•The a-C:H:SiOx coating facilitates endothelization of implants in thoracic aorta.•The a-C:H:SiOx coating reduces pro-inflammatory interleukin secretion.•The coating elevates the concentration of anti-inflammatory interleukin IL-1Ra.