Details

Autor(en) / Beteiligte

• Buckley, Thomas M.W.
• Jolly, Jasleen K.
• Josan, Amandeep Singh
• Wood, Laura J.
• Cehajic‐Kapetanovic, Jasmina
• MacLaren, Robert E.

Titel

Clinical applications of microperimetry in RPGR‐related retinitis pigmentosa: a review

Ist Teil von

• Acta ophthalmologica (Oxford, England), 2021-12, Vol.99 (8), p.819-825

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Microperimetry, or fundus‐tracked perimetry, is a precise static‐automated perimetric technique to assess central retinal function. As visual acuity only deteriorates at a late disease stage in RPGR‐related retinitis pigmentosa (RP), alternative markers for disease progression are of great utility. Microperimetry assessment has been of critical value as an outcome measure in a recently reported phase I/II gene therapy trial for RPGR‐related RP, both in terms of detecting safety and efficacy signals. Here, we performed a review of the literature. We describe the principles of microperimetry before outlining specific parameters that may be useful as outcome measures in clinical trial settings. The current state of structure–function correlations between short‐wavelength autofluorescence, optical coherence tomography and adaptive optics in RPGR‐related retinitis pigmentosa are also summarized.