Details

Autor(en) / Beteiligte

• BONICHON, Françoise
• de BAERE, Thierry
• Berdelou, Amandine
• Leboulleux, Sophie
• Giraudet, Anne-Laure
• Cuinet, Marie
• Drui, Delphine
• Liberge, Renan
• Kelly, Antony
• Tenenbaum, Florence
• Legmann, Paul
• Do Cao, Christine
• Leenhardt, Laurence
• Toubeau, Michel
• Godbert, Yann
• Palussière, Jean

Titel

Percutaneous thermal ablation of lung metastases from thyroid carcinomas. A retrospective multicenter study of 107 nodules. On behalf of the TUTHYREF network

Ist Teil von

• Endocrine, 2021-06, Vol.72 (3), p.798-808

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose To determine efficacy and safety of thermal ablation (TA) for the local treatment of lung metastases of thyroid cancer. Methods We retrospectively studied 47 patients from 10 centers treated by TA (radiofrequency, microwaves, and cryoablation) over 10 years. The endpoints were overall survival (OS), local efficacy, complications (CTCAE classification), and factors associated with survival. OS curves after first TA were built using the Kaplan–Meier method and compared with the log-rank test. Results A total of 107 lung metastases during 75 sessions were treated by radiofrequency ( n  = 56), microwaves ( n  = 9), and cryoablation ( n  = 10). Median follow-up time after TA was 5.2 years (0.2–13.3). OS was 93% at 2 years (95% confidence interval (CI): 86–94) and 79% at 3 years (95% CI: 66–91). On univariate and multivariate analysis with a Cox model, histology was the only significant factor for OS. OS at 3 years was 94% for follicular, oncocytic, or papillary follicular variant carcinomas, compared to 59% for papillary, medullary, insular or anaplastic carcinomas ( P  = 0.0001). The local control rate was 98.1% at 1 year and 94.8% at 2, 3, 4, and 5 years. Morbidity was low with no major complications (grade 4 and 5 CTCAE) and no complications in 29 of 75 sessions (38.7%). Conclusions TA is a useful, safe and effective option for local treatment of lung metastases from thyroid carcinoma. Prolonged OS was obtained, especially for lung metastases from follicular, oncocytic, or papillary follicular variant carcinomas. Achieving disease control with TA delays the need for systemic treatment.