Details

Autor(en) / Beteiligte

• Volz, Erik
• Mishra, Swapnil
• Chand, Meera
• Barrett, Jeffrey C
• Johnson, Robert
• Geidelberg, Lily
• Hinsley, Wes R
• Laydon, Daniel J
• Dabrera, Gavin
• O'Toole, Áine
• Amato, Robert
• Ragonnet-Cronin, Manon
• Harrison, Ian
• Jackson, Ben
• Ariani, Cristina V
• Boyd, Olivia
• Loman, Nicholas J
• McCrone, John T
• Gonçalves, Sónia
• Jorgensen, David
• Myers, Richard
• Hill, Verity
• Jackson, David K
• Gaythorpe, Katy
• Groves, Natalie
• Sillitoe, John
• Kwiatkowski, Dominic P
• Flaxman, Seth
• Ratmann, Oliver
• Bhatt, Samir
• Hopkins, Susan
• Gandy, Axel
• Rambaut, Andrew
• Ferguson, Neil M

Titel

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Ist Teil von

• Nature (London), 2021-05, Vol.593 (7858), p.266-269

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The SARS-CoV-2 lineage B.1.1.7, designated variant of concern (VOC) 202012/01 by Public Health England , was first identified in the UK in late summer to early autumn 2020 . Whole-genome SARS-CoV-2 sequence data collected from community-based diagnostic testing for COVID-19 show an extremely rapid expansion of the B.1.1.7 lineage during autumn 2020, suggesting that it has a selective advantage. Here we show that changes in VOC frequency inferred from genetic data correspond closely to changes inferred by S gene target failures (SGTF) in community-based diagnostic PCR testing. Analysis of trends in SGTF and non-SGTF case numbers in local areas across England shows that B.1.1.7 has higher transmissibility than non-VOC lineages, even if it has a different latent period or generation time. The SGTF data indicate a transient shift in the age composition of reported cases, with cases of B.1.1.7 including a larger share of under 20-year-olds than non-VOC cases. We estimated time-varying reproduction numbers for B.1.1.7 and co-circulating lineages using SGTF and genomic data. The best-supported models did not indicate a substantial difference in VOC transmissibility among different age groups, but all analyses agreed that B.1.1.7 has a substantial transmission advantage over other lineages, with a 50% to 100% higher reproduction number.