Details

Autor(en) / Beteiligte

• Cuc, Nguyen Thi
• Yen, Duong Thi Hai
• Yen, Pham Hai
• Hang, Dan Thi Thuy
• Tai, Bui Huu
• Seo, Yohan
• Namkung, Wan
• Kim, Seung Hyun
• Cuong, Pham Van
• Kiem, Phan Van
• Nhiem, Nguyen Xuan
• Ngoc, Tran Minh

Titel

Dihydrostilbene glycosides from Camellia sinensis var. assamica and their cytotoxic activity

Ist Teil von

• Natural product research, 2022-08, Vol.36 (15), p.3931-3937

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Three undescribed dihydrostilbene glycosides, 3,5-dihydroxyldihydrostilbene 4′-O-[6′′-O-(4′′′-hydroxylbenzoyl)]-β-D-glucopyranoside (1), 3,5-dihydroxyldihydrostilbene 4′-O-(6′′-O-galloyl)-β-D-glucopyranoside (2), and 3,5-dihydroxyldihydrostilbene 4′-O-[6′′-O-(3′′′,4′′′-dimethoxyl)galloyl]-β-D-glucopyranoside (3), and seven known compounds, kaempferol 3-O-β-D-glucopyranoside (4), isoquercitrin (5), kaempferol 3-O-α-L-rhamnoside (6), quercitrin (7), (6S,9R)-roseoside (8), (-)-epicatechin 3-O-gallate (9), and (-)-epigallocatechin 3-O-gallate (10) have been isolated from the methanol extract of the leaves of Camellia sinensis var. assamica (J.W.Mast.) Kitam. (synnonym of Camellia assamica (Mast.) H.T.Chang) (Theaceae). Their structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. All compounds were evaluated for cytotoxic activity against human oral cancer (CAL27) and human breast cancer (MDAMB231) cell lines. Compound 10 showed significant cytotoxic activity against CAL27 and MDAMB231 cell lines with IC 50 values of 9.78 ± 0.25 and 3.27 ± 0.18 μM, respectively, compared to those of positive control, capecitabine (IC 50 values of 8.20 ± 0.75 and 5.20 ± 0.89 μM).