Details

Autor(en) / Beteiligte

• Galli, Fabio
• Di Bartolomeo, Maria
• Ronzoni, Monica
• Banzi, Maria
• Pasini, Felice
• Bozzarelli, Silvia
• Ferrari, Daris
• Montesarchio, Vincenzo
• Mambrini, Andrea
• Ciuffreda, Libero
• Pusceddu, Valeria
• Carlomagno, Chiara
• Bidoli, Paolo
• Amoroso, Domenico
• Frassineti, Luca
• Pastorino, Alessandro
• De Stefano, Alfonso
• Labianca, Roberto
• Rosati, G.
• Montesarchio, V.
• Iaffaioli, R.V.
• Nasti, G.
• Daniele, B.
• Lonardi, S.
• Pella, N.
• Marchetti, Roma P.
• Romiti, A.
• Foa, P.
• Zaniboni, A.
• Labianca, R.
• Mosconi, S.
• Sobrero, A.
• Bidoli, P.
• Cazzaniga, M.
• Beretta, G.D.
• Corsi, D.C.
• Cortesi, E.
• Barni, S.
• Petrelli, F.
• Allione, P.
• D'Arco, A.M.
• Valmadre, G.
• Piazza, E.
• Veltri, E.
• Tumulo, S.
• Cascinu, S.
• Granetto, C.
• Giordano, M.
• Moroni, M.
• Di Seri, M.
• Nuzzo, A.
• Gori, S.
• Aglietta, M.
• Tonini, G.
• Benasso, M.
• Graiff, C.
• Bravi, S.
• Frontini, L.
• Rota, S.
• Cozzi, L.
• Cantore, M.
• Maiello, E.
• Cinieri, S.
• Romito, S.
• Gebbia, V.
• Santoro, A.
• Artioli, F.
• Mattioli, R.
• Contu, A.
• Di Costanzo, F.
• Leonardi, F.
• Passalacqua, R.
• Sozzi, P.
• D'Amico, M.
• Pasquini, E.
• Gambi, A.
• Faedi, M.
• Cruciani, G.
• Bajetta, E.
• Gianni, L.
• Ronzoni, M.
• Massidda, B.
• Scartozzi, M.
• Zampino, M.G.
• Bochicchio, A.M.
• Frustaci, S.
• Pavesi, L.
• Verusio, C.
• Pinotti, G.
• Iop, A.
• De Placido, S.
• Carlomagno, C.
• Adamo, V.
• Ficorella, C.
• Greco, E.
• Rulli, E.
• Galli, F.
• Poli, D.
• Porcu, L.
• Torri, V.

Titel

Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial

Ist Teil von

• European journal of cancer (1990), 2021-05, Vol.148, p.190-201

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Previous studies on oxaliplatin and fluoropyrimidines as adjuvant therapy in older patients with stage III colon cancer (CC) produced conflicting results. We assessed the impact of age on time to tumour recurrence (TTR), disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) in 2360 patients with stage III CC (1667 aged <70 years and 693 ≥ 70 years) randomised to receive 3 or 6 months of FOLFOX or CAPOX within the frame of the phase III, TOSCA study. Older patients compared with younger ones presented more frequently an Eastern Cooperative Oncology Group performance status equal to 1 (10.5% vs 3.3%, p < 0.001), a greater number of right-sided tumours (40.9% vs 26.6%, p < 0.001), and were at higher clinical risk (37.2% vs 33.2%, p = 0.062). The treatments were almost identical in the two cohorts (p = 0.965). We found a greater proportion of dose reductions (46.7% vs 41.4%, p = 0.018), treatment interruptions (26.1% vs 19.3%, p < 0.001) and a higher proportion of recurrences (24.2% vs 20.3%, p = 0.033) in the older patients. The multivariable analysis of the TTR did not indicate a statistically significant effect of age (hazard ratio [HR]: 1.19; 95% confidence interval [CI]: 0.98–1.44; p = 0.082). The HR comparing older with younger patients was 1.34 (95% CI: 1.12–1.59; p = 0.001) for DFS, 1.58 (95% CI: 1.26–1.99; p < 0.001) for OS, and 1.28 (95% CI: 0.96–1.70; p = 0.089) for CSS. Worse prognostic factors and reduced treatment compliance have a negative impact on the efficacy of oxaliplatin-based adjuvant therapy in older patients. •The outcome of oxaliplatin as an adjuvant therapy in elderly patients with colon cancer is doubt.•Worse prognostic factors and reduced compliance have a negative impact on its effectiveness.•Fluoropyrimidine monotherapy is an appropriate choice for most elderly patients.•Only fit elderly patients should receive oxaliplatin as an adjuvant therapy.