Details

Autor(en) / Beteiligte

• Diao, Yong-Kang
• Liu, Jun-Wei
• Wu, Han
• Wang, Ming-Da
• Fan, Xin-Ping
• Chen, Ting-Hao
• Wang, Jian-Yu
• Zhou, Ya-Hao
• Gu, Wei-Min
• Wang, Hong
• Li, Jie
• Liang, Ying-Jian
• Chen, Zhi-Yu
• Lau, Wan Yee
• Liang, Lei
• Li, Chao
• Zhang, Cheng-Wu
• Shen, Feng
• Huang, Dong-Sheng
• Yang, Tian

Titel

Long-term oncologic outcomes of liver resection for hepatocellular carcinoma in adolescents and young adults: A multicenter study from a hepatitis B virus-endemic area

Ist Teil von

• The American journal of surgery, 2021-10, Vol.222 (4), p.751-758

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) in areas with endemic hepatitis B virus infection. We sought to characterize clinical features and long-term outcomes among AYAs versus older adults (OAs) who underwent HCC resection. From a Chinese multicenter database, patients were categorized as AYA (aged 13–39 years) versus OA (aged ≥40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were compared. Multivariable Cox-regression analyses were performed to identify the impact of age on OS and TTR. Among 1952 patients, 354(22.2%) were AYAs. AYAs were less likely to have cirrhosis yet were likely to have advanced tumor pathological characteristics than OAs. Postoperative morbidity and mortality were comparable. Compared with OAs, AYAs had a comparable OS but a decreased TTR. Multivariable analyses identified that young age (<40 years) was independently associated with poorer TTR. Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among AYAs. •Adolescents and young adults (AYA, 13–39 years) undergoing liver resection for hepatocellular carcinoma (HCC) were less often to have cirrhosis but more likely to have advanced tumor pathological characteristics than older adults (OA, ≥ 40 years).•Postoperative morbidity and mortality were comparable between AYAs and OAs with HCC.•Young age (<40 years) was independently associated with increased recurrence rate after curative HCC resection.