Details

Autor(en) / Beteiligte

• Tian, Xiao-Peng
• Ma, Shu-Yun
• Young, Ken H.
• Ong, Choon Kiat
• Liu, Yan-Hui
• Li, Zhi-Hua
• Zhai, Qiong-Li
• Huang, Hui-Qiang
• Lin, Tong-Yu
• Li, Zhi-Ming
• Xia, Zhong-Jun
• Zhong, Li-Ye
• Rao, Hui-Lan
• Li, Mei
• Cai, Jun
• Zhang, Yu-Chen
• Zhang, Fen
• Su, Ning
• Li, Peng-Fei
• Zhu, Feng
• Xu-Monette, Zijun Y.
• Wong, Esther Kam Yin
• Ha, Jeslin Chian Hung
• Khoo, Lay Poh
• Ai, Le
• Cheng, Run-Fen
• Lim, Jing Quan
• de Mel, Sanjay
• Ng, Siok-Bian
• Lim, Soon Thye
• Cai, Qing-Qing

Titel

A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma

Ist Teil von

• Blood, 2021-08, Vol.138 (6), p.452-463

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Current prognostic scoring systems based on clinicopathologic variables are inadequate in predicting the survival and treatment response of extranodal natural killer/T-cell lymphoma (ENKTL) patients undergoing nonanthracyline-based treatment. We aimed to construct a classifier based on single-nucleotide polymorphisms (SNPs) for improving predictive accuracy and guiding clinical decision making. Data from 722 patients with ENKTL from international centers were analyzed. A 7-SNP–based classifier was constructed using LASSO Cox regression in the training cohort (n = 336) and further validated in the internal testing cohort (n = 144) and in 2 external validation cohorts (n = 142 and n = 100). The 7-SNP–based classifier showed good prognostic predictive efficacy in the training cohort and the 3 validation cohorts. Patients with high- and low-risk scores calculated by the classifier exhibited significantly different progression-free survival (PFS) and overall survival (OS) (all P < .001). The 7-SNP–based classifier was further proved to be an independent prognostic factor by multivariate analysis, and its predictive accuracy was significantly better than clinicopathological risk variables. Application of the 7-SNP–based classifier was not affected by sample types. Notably, chemotherapy combined with radiotherapy significantly improved PFS and OS vs radiotherapy alone in high-risk Ann Arbor stage I patients, whereas there was no statistical difference between the 2 therapeutic modalities among low-risk patients. A nomogram was constructed comprising the classifier and clinicopathological variables; it showed remarkably better predictive accuracy than either variable alone. The 7-SNP–based classifier is a complement to existing risk-stratification systems in ENKTL, which could have significant implications for clinical decision making for patients with ENKTL. •The 7-SNP-based classifier is an effective and reliable predictor of survival for patients with ENKTL.•The 7-SNP-based signature can be used as a supplement to current risk indicators, aiding clinical decision making. [Display omitted]