Details

Autor(en) / Beteiligte

• Massarotti, Claudia
• Sbragia, Elvira
• Boffa, Giacomo
• Vercelli, Caterina
• Zimatore, Giovanni Bosco
• Cottone, Salvatore
• Frau, Jessica
• Raiola, Annamaria
• Varaldo, Riccardo
• Mancardi, Gianluigi
• Inglese, Matilde
• Anserini, Paola

Titel

Menstrual cycle resumption and female fertility after autologous hematopoietic stem cell transplantation for multiple sclerosis

Ist Teil von

• Multiple sclerosis, 2021-11, Vol.27 (13), p.2103-2107

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Data on fertility after autologous hematopoietic stem cell transplantation (aHSCT) in women with multiple sclerosis (MS) are inconclusive. This study aims to report on post-aHSCT menstrual resumption in a multi-center MS-women cohort. Out of 43 women, 30 (70%) recovered menses after a mean time of 6.8 months. Older age (odds ratio (OR) = 0.5, p < 0.0001) and previous pulsed cyclophosphamide (OR = 0.44, p = 0.005) were independently associated with a reduced menstrual recovery probability. Conditioning regimens’ intensity resulted not associated with post-procedure amenorrhea. Our results highlight younger age as significantly associated with menses recovery; proper fertility counseling for MS women candidated to aHSCT both prior- and post-transplantation is therefore warranted.