Details

Autor(en) / Beteiligte

• Lund, Kit P.
• Eriksson, Frank
• Hauge, Anne W.
• Mora-Jensen, Helena I.
• Sørensen, Søren S.
• Bruunsgaard, Helle

Titel

The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2021-05, Vol.226, p.108711-108711, Article 108711

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The importance of the human leukocyte antigen (HLA) system in kidney transplantation is well-known, but it remains unexplored if patient HLA antigens constitute independent risk factors in complications after transplantation. We hypothesized that specific HLA class II phenotypes associated with immune-mediated disease (HLA-IMD) predispose to immunological activity and/or complications after kidney transplantation. Based on the literature we defined HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated associations between HLA-IMD phenotypes in patients, biomarkers of systemic chronic inflammation at the time of transplantation, and the outcome after kidney transplantation in a retrospective cohort study of 611 kidney transplanted patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality after transplantation in Cox analyses with adjustments for confounders. Data support the hypothesis that specific HLA class II phenotypes affects immunological pathways that determine the midterm clinical outcome of kidney transplantation. •Specific HLA class II phenotypes are associated with low-grade inflammation.•The HLA-DR4-DQ8 phenotype is associated with mortality after kidney transplantation.•Associations between HLA-DR4-DQ8 and mortality persisted in adjusted analyses.