Details

Autor(en) / Beteiligte

• Vincentiis, Silvia
• Alcantara, Juliana A.
• Rzezak, Patricia
• Kerr, Daniel S.
• Gattaz, Wagner F.
• van der Linden, Helio
• dos Santos, Bernardo
• Arruda, Francisco
• Chaim-Avancini, Tiffany
• Serpa, Mauricio H.
• Fernandes, Fernando
• Moreno, Ricardo A.
• Busatto, Geraldo F.
• Alessi, Ruda
• Demarque, Renata
• Valente, Kette D.

Titel

Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis

Ist Teil von

• Epilepsy & behavior, 2021-04, Vol.117, p.107854-107854, Article 107854

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• •5-HTT linked polymorphic region polymorphism is not related to TLE-HS with and without depression.•5-HTTVNTR polymorphism is not related to TLE-HS with and without depression.•The 12-allele of the 5-HTTVNTR is related to a family history of patients with TLE-HS. Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms – 5-HTTLPR and 5-HTTVNTR – and the presence of mood disorders in patients with TLE-HS. We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were genotyped for the 5-HTTLPR and 5-HTTVNTR polymorphisms. No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013). In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics.