Details

Autor(en) / Beteiligte

• Alpaugh, Melanie
• Cicchetti, Francesca

Titel

Huntington’s disease: lessons from prion disorders

Ist Teil von

• Journal of neurology, 2021-09, Vol.268 (9), p.3493-3504

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2021

Quelle

Springer Journals

Beschreibungen/Notizen

• Decades of research on the prion protein and its associated diseases have caused a paradigm shift in our understanding of infectious agents. More recent years have been marked by a surge of studies supporting the application of these findings to a broad array of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Here, we present evidence to suggest that Huntington’s disease, a monogenic disorder of the central nervous system, shares features with prion disorders and that, it too, may be governed by similar mechanisms. We further posit that these similarities could suggest that, like other common neurodegenerative disorders, sporadic forms of Huntington’s disease may exist.