Details

Autor(en) / Beteiligte

• Kang, Kun‐Tai
• Chiu, Shuenn‐Nan
• Weng, Wen‐Chin
• Lee, Pei‐Lin
• Hsu, Wei‐Chung

Titel

24‐Hour Ambulatory Blood Pressure Variability in Children with Obstructive Sleep Apnea

Ist Teil von

• The Laryngoscope, 2021-09, Vol.131 (9), p.2126-2132

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Objective To evaluate blood pressure (BP) variability in 24‐hour ambulatory BP monitoring in children with obstructive sleep apnea (OSA). Study Design Case series study. Methods Children aged 4 to 16 years with clinical symptoms were recruited in a tertiary medical center. Overnight polysomnography and 24‐hour recordings of ambulatory BP were performed for each child. The severity of OSA was classified as primary snoring (apnea‐hypopnea index [AHI] < 1), mild OSA (1 ≤ AHI < 5), moderate OSA (10 > AHI ≥ 5), and severe OSA (AHI ≥ 10). The standard deviation of mean BP was used as an indicator of BP variability. Results A total of 550 children were included (mean age: 7.6 years; 70% were boys; 20% were obese). Compared with the children with primary snoring, children with severe OSA exhibited significantly higher nighttime systolic BP (108.0 vs. 100.5 mmHg, P < .001), nighttime diastolic BP (58.9 vs 55.6 mmHg, P = .002), nighttime mean arterial pressure (75.3 vs. 70.5 mmHg, P < .001), nighttime systolic BP load (40.5% vs. 25.0%, P < .001), nighttime diastolic BP load (25.3% vs. 12.9%, P < .001), and nighttime systolic BP variability (11.4 vs. 9.6, P = .001). Multiple linear regression analyses revealed an independent association between AHI and nighttime systolic BP variability (regression coefficient = 0.31, 95% CI = 0.06–0.56, P = .015) after adjustment for age, gender, adiposity, and hypertensive status. Conclusions OSA in children is associated with increased BP and BP variability. Level of Evidence 4 Laryngoscope, 131:2126–2132, 2021