Biochemical and biophysical research communications, 2021-03, Vol.546, p.65-73
2021
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- Autor(en) / Beteiligte
- Titel
- The differentiation of colorectal cancer is closely relevant to m6A modification
- Ist Teil von
- Biochemical and biophysical research communications, 2021-03, Vol.546, p.65-73
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2021
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The occurrence and development of tumors cannot be separated from the influence of differentiation at different stages and levels. Our study found that E-cadherin was significantly increased in cell model induced by sodium butyrate and cell density, while METTL3, METTL16 and WTAP were decreased during the differentiation of cells. In the clinicopathological tissues, E-cadherin was low expressed in poorly differentiated tumor tissues and above three regulators were highly expressed in poorly differentiated tissues. At the levels of clinicopathological differentiation, tissue differentiation and cell differentiation, the result indicated that the poor prognosis of colorectal cancer (CRC) may be closely related to high expression of total m6A level and high expression of METTL3, METTL16 and WTAP. •High total m6A level and high expression of METTL3, METTL16, WTAP may be a malignant signature in CRC.•METTL3, METTL16 and WTAP showed a significant downward trend in differentiation model.•High total m6A and high expression of METTL3, METTL16, WTAP are relevant to low differentiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1016/j.bbrc.2021.02.001Titel-ID: cdi_proquest_miscellaneous_2489263425
- Format
- –
- Schlagworte
- Adenosine - analogs & derivatives, Adenosine - metabolism, Butyric Acid - pharmacology, Cell Cycle Proteins, Cell Differentiation - drug effects, Cell Line, Tumor, Colorectal cancer, Colorectal Neoplasms - genetics, Colorectal Neoplasms - metabolism, Colorectal Neoplasms - pathology, Contact Inhibition - drug effects, Differentiation, E-cadherin, Female, Gene Expression Regulation, Neoplastic - drug effects, Humans, Male, Methyltransferases, METTL3, Middle Aged, Protein Biosynthesis - drug effects, RNA Splicing Factors, Transcription, Genetic - drug effects, WTAP