Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ecofriendly novel synthesis of tertiary composite based on cellulose and myco-synthesized selenium nanoparticles: Characterization, antibiofilm and biocompatibility
Ist Teil von
International journal of biological macromolecules, 2021-04, Vol.175, p.294-303
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2021
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Microbial infections are considered common and dangerous for humans among other infections; therefore the synthesis of high efficacy antimicrobial and anti-biofilm composites is continuous to fight microbial resistance. In our study, a new and novel tertiary composite (TC) was synthesized, it composed of TEMPO cellulose (TOC), chitosan, starch, and myco-synthesized Se-NPs. Myco-synthesized Se-NPs and TC were fully characterized using UV, FT-IR, XRD, SEM with EDX, particle distribution, and mapping. The antimicrobial and anti-biofilm properties of selenium nanoparticles (Se-NPs) were effectively established for Pseudomonas aeruginosa and Staphylococcus aureus biofilms. The possible impact of myco-synthesized novel cellulose-based selenium nanoparticles tertiary composite on the biofilm formation of P. aeruginosa, S. aureus, and Candida albicans was evaluated in this study. TC exhibited constant biofilm inhibition against P. aeruginosa, S. aureus, and C. albicans, while the results obtained from cytotoxicity of Se-NPs and TC showed that, alteration occurred in the normal cell line of lung fibroblast cells (Wi-38) was shown as loss of their typical cell shape, granulation, loss of monolayer, shrinking or rounding of Wi-38 cell with an IC50 value of where 461 and 550 ppm respectively.
•Novel tertial composite based on TEMPO cellulose, chitosan, starch and biosynthesized selenium nanoparticles was synthesized.•This composite was fully characterized using UV, FT-IR, XRD, SEM with EDX, particle distribution and mapping.•This promising composite exhibited potential anti-biofilm activity which produced by microbes.