Nature medicine, 2021-04, Vol.27 (4), p.620-621
2021
Details
- Autor(en) / Beteiligte
- Titel
- Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera
- Ist Teil von
- Nature medicine, 2021-04, Vol.27 (4), p.620-621
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/s41591-021-01270-4Titel-ID: cdi_proquest_miscellaneous_2487749595
- Format
- –
- Schlagworte
- BNT162 Vaccine, Coronaviruses, COVID-19 Vaccines - immunology, Deletion, Gene mutations, Genetic aspects, Humans, Mutation, Neutralization, Neutralization Tests, SARS-CoV-2 - immunology, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Spike Glycoprotein, Coronavirus - genetics, Spike Glycoprotein, Coronavirus - immunology, Spikes, Vaccination, Vaccines, Viral diseases, Viral proteins, Virus research, Viruses