Details

Autor(en) / Beteiligte

• Sharma, Jyoti
• Chaudhary, Sanjiv
• Bajaj, Mohit
• Nair, Nayana P.
• Thiyagarajan, Varunkumar

Titel

Rotavirus Gastroenteritis Hospitalizations Among Under-5 Children in Northern India

Ist Teil von

• Indian journal of pediatrics, 2021-03, Vol.88 (Suppl 1), p.28-34

Ort / Verlag

New Delhi: Springer India

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective To study epidemiological profile, prevalence, and molecular epidemiology of RVGE in hospitalized under-5 children at a tertiary care teaching rural hospital located in sub-Himalayan belt of Northern India. Methods This was a hospital-based surveillance study done over 4 y (2016–2019) including under-5 children hospitalized with acute gastroenteritis (AGE). Demographic and clinical parameters were recorded in a pre-designed performa. After consent, stool samples were collected and sent to Christian Medical College (CMC), Vellore for RV screening by enzyme immunoassay (EIA). Each EIA-positive sample was further subjected to G and P typing using published methods. Results Out of total 851 included children, rotavirus gastroenteritis (RVGE) was detected in 23.03% (196/851) cases by EIA. The highest incidence for RVGE-positive cases (40.43%) was observed in 2016 with gradual decline over next 3 y. Maximum cases of diarrhea were observed in 12–23 mo age group along with highest rotavirus detection. G3P[8] was most common genotype (46.94%) found, followed by G1P[8] (13.78%), G2P[4] (4.59%), G1P[6] (8.16%) and G9P[4] (3.57%). Mixed genotype was seen in 13.78% of total cases. Conclusion This study summarizes the changing trends in the epidemiology of RVGE in Northern India along with the major circulating genotypes postvaccine introduction.