Details

Autor(en) / Beteiligte

• Zhang, Jing
• Chen, Chen
• Li, Anning
• Jing, Weiqiang
• Sun, Peng
• Huang, Xueyang
• Liu, Yingchao
• Zhang, Shengchang
• Du, Wei
• Zhang, Rui
• Liu, Ying
• Gong, Aihua
• Wu, Jibiao
• Jiang, Xinyi

Titel

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Ist Teil von

• Nature nanotechnology, 2021-05, Vol.16 (5), p.538-548

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2021

Quelle

Springer Nature - Connect here FIRST to enable access

Beschreibungen/Notizen

• Immunotherapies have revolutionized intervention strategies for many primary cancers, but have not improved the outcomes of glioblastoma multiforme (GBM), which remains one of the most lethal malignant cerebral tumours. Here we present an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, which mitigates its relapse. The hydrogel comprises a tumour-homing immune nanoregulator, which induces immunogenic cell death and suppression of indoleamine 2,3-dioxygenase-1, and chemotactic CXC chemokine ligand 10, for a sustained T-cell infiltration. When delivered in the resected tumour cavity, the hydrogel system mimics a ‘hot’ tumour-immunity niche for attacking residual tumour cells and significantly suppresses postoperative GBM recurrence. Our work provides an alternative strategy for conferring effective tumoricidal immunity in GBM patients, which may have a broad impact in the immunotherapy of ‘cold’ tumours after surgical intervention. Tumour relapse after resection undermines the efficacy of surgical treatment for glioblastoma multiforme. Here the authors present a hydrogel that can be injected in the tumour cavity after resection and that promotes antitumour immunity, reducing postoperative cancer growth in animal models.