Details

Autor(en) / Beteiligte

• Yu, Kai
• Alzahrani, Amal
• Khoddami, Sara
• Ferreira, Demian
• Scotland, Kymora B.
• Cheng, John T. J.
• Yazdani‐Ahmadabadi, Hossein
• Mei, Yan
• Gill, Arshdeep
• Takeuchi, Lily E.
• Yeung, Edbert
• Grecov, Dana
• Hancock, Robert E. W.
• Chew, Ben H.
• Lange, Dirk
• Kizhakkedathu, Jayachandran N.

Titel

Self‐Limiting Mussel Inspired Thin Antifouling Coating with Broad‐Spectrum Resistance to Biofilm Formation to Prevent Catheter‐Associated Infection in Mouse and Porcine Models

Ist Teil von

• Advanced healthcare materials, 2021-03, Vol.10 (6), p.e2001573-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Catheter‐associated urinary tract infections (CAUTIs) are one of the most commonly occurring hospital‐acquired infections. Current coating strategies to prevent catheter‐associated biofilm formation are limited by their poor long‐term efficiency and limited applicability to diverse materials. Here, the authors report a highly effective non‐fouling coating with long‐term biofilm prevention activity and is applicable to diverse catheters. The thin coating is lubricous, stable, highly uniform, and shows broad spectrum prevention of biofilm formation of nine different bacterial strains and prevents the migration of bacteria on catheter surface. The coating method is adapted to human‐sized catheters (both intraluminal and extraluminal) and demonstrates long‐term biofilm prevention activity over 30 days in challenging conditions. The coated catheters are tested in a mouse CAUTI model and demonstrate high efficiency in preventing bacterial colonization of both Gram‐positive and Gram‐negative bacteria. Furthermore, the coated human‐sized Foley catheters are evaluated in a porcine CAUTI model and show consistent efficiency in reducing biofilm formation by Escherichia coli (E. coli) over 95%. The simplicity of the coating method, the ability to apply this coating on diverse materials, and the high efficiency in preventing bacterial adhesion increase the potential of this method for the development of next generation infection resistant medical devices. A highly effective non‐fouling coating with long‐term biofilm prevention activity is developed and applied to diverse catheters. The thin coating is lubricous, stable, highly uniform, and shows broad‐spectrum prevention of biofilm formation. The coated human‐sized Foley catheters are evaluated in a porcine CAUTI model and show consistent efficiency in reducing biofilm formation by E. coli over 95%.