Details

Autor(en) / Beteiligte

• de la Fouchardiere, Arnaud
• Blokx, Willeke
• van Kempen, Léon C.
• Luzar, Boštjan
• Piperno-Neumann, Sophie
• Puig, Susana
• Alos, Llucia
• Calonje, Eduardo
• Massi, Daniela

Titel

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants

Ist Teil von

• Virchows Archiv : an international journal of pathology, 2021-07, Vol.479 (1), p.3-11

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2021

Quelle

SpringerLink

Beschreibungen/Notizen

• The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular tools, both in the setting of general pathology labs and expert centers. Moreover, recommendations regarding the re-excision and clinical follow-up are given to support decision-making in multidisciplinary tumor boards.